Patterns of Mitochondrial TSPO Binding in Cerebral Small Vessel Disease: An <i>in vivo</i> PET Study With Neuropathological Comparison.

ABSTRACT: Small vessel disease (SVD) is associated with cognitive impairment in older age and be implicated in vascular dementia. Post-mortem studies show proliferation of activated microglia in the affected white matter. However, the role of inflammation in SVD pathogenesis is incompletely understood and better biomarkers are needed. We hypothesized that expression of the 18 kDa translocator protein (TSPO), a marker of microglial activation, would be higher in SVD. Positron emission tomography (PET) was performed with the second-generation TSPO ligand [¹¹C]PBR28 in 11 participants with SVD. TSPO binding was evaluated by a two-tissue compartment model, with and without a vascular binding component, in white matter hyperintensities (WMH) and normal-appearing white matter (NAWM). In post-mo

SUBMITTER: Wright P 

PROVIDER: S-EPMC7596201 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature