Extracellular Control of Radial Glia Proliferation and Scaffolding During Cortical Development and Pathology.

ABSTRACT: During the development of the cortex, newly generated neurons migrate long-distances in the expanding tissue to reach their final positions. Pyramidal neurons are produced from dorsal progenitors, e.g., radial glia (RGs) in the ventricular zone, and then migrate along RG processes basally toward the cortex. These neurons are hence dependent upon RG extensions to support their migration from apical to basal regions. Several studies have investigated how intracellular determinants are required for RG polarity and subsequent formation and maintenance of their processes. Fewer studies have identified the influence of the extracellular environment on this architecture. This review will focus on extracellular factors which influence RG morphology and pyramidal neuronal migration during normal de

SUBMITTER: Ferent J 

PROVIDER: S-EPMC7596222 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature