Novel Prodiginine Derivatives Demonstrate Bioactivities on Plants, Nematodes, and Fungi.

ABSTRACT: Bacterial metabolites represent an invaluable source of bioactive molecules which can be used as such or serve as chemical frameworks for developing new antimicrobial compounds for various applications including crop protection against pathogens. Prodiginines are tripyrrolic, red-colored compounds produced by many bacterial species. Recently, due to the use of chemical-, bio-, or mutasynthesis, a novel group of prodiginines was generated. In our study, we perform different assays to evaluate the effects of prodigiosin and five derivatives on nematodes and plant pathogenic fungi as well as on plant development. Our results showed that prodigiosin and the derivatives were active against the bacterial feeding nematode Caenorhabditis elegans in a concentration- and derivative-dependent

SUBMITTER: Habash SS 

PROVIDER: S-EPMC7596250 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature