Association between the IL10 rs1800896 Polymorphism and Tardive Dyskinesia in Schizophrenia.

ABSTRACT:

Objective

Interleukin-10 (IL-10) is a major immunoregulatory cytokine and its gene plays a fundamental role in anti-inflammatory and immunosuppressive activity. This study aimed to examine the association between the IL10 gene promoter -1082G/A polymorphism (rs1800896) and tardive dyskinesia (TD) in schizophrenia.

Methods

Two hundred and eighty unrelated Korean schizophrenic patients participated in this study (105 TD and 175 non-TD patients). TD was diagnosed using the Research Diagnostic Criteria for TD and Abnormal Involuntary Movement Scale (AIMS). Genotyping was performed by RT-PCR and high-resolution melting curve analysis.

Results

The distributions of genotypic frequencies did not differ between patients with and without TD (χ2=4.33, p=0.115). However, allelic

SUBMITTER: Choi KY 

PROVIDER: S-EPMC7596282 | biostudies-literature | 2020 Oct

REPOSITORIES: biostudies-literature