Role of Mitochondria in Cancer Immune Evasion and Potential Therapeutic Approaches.

ABSTRACT: The role of mitochondria in cancer formation and progression has been studied extensively, but much remains to be understood about this complex relationship. Mitochondria regulate many processes that are known to be altered in cancer cells, from metabolism to oxidative stress to apoptosis. Here, we review the evolving understanding of the role of mitochondria in cancer cells, and highlight key evidence supporting the role of mitochondria in cancer immune evasion and the effects of mitochondria-targeted antitumor therapy. Also considered is how knowledge of the role of mitochondria in cancer can be used to design and improve cancer therapies, particularly immunotherapy and radiation therapy. We further offer critical insights into the mechanisms by which mitochondria influence tumor immune

SUBMITTER: Klein K 

PROVIDER: S-EPMC7596324 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature