Meta-analysis of brain metabolite differences in HIV infection.

ABSTRACT:

Background

Numerous studies have used magnetic resonance spectroscopy (MRS) neurometabolite measurements to study HIV infection effects. While many have reported differences in total N-Acetylaspartate (tNAA), myo-Inositol (mI), and total Choline (tCho), there have been no meta-analyses performed to evaluate concordance across studies.

Purpose

To evaluate the consistency of HIV serostatus effects on brain metabolites.

Study selection

The sample included studies conducted between 1993 and 2019 reporting HIV infection effects measured using proton MRS. tNAA/tCr ratios (21 papers), tCho/tCr ratios (21 papers), mI/tCr ratios (17 papers) and quantitative tCr (9 papers), sampling from basal ganglia (BG), gray matter (GM), and white matter (WM) were included.

Data analysis

SUBMITTER: Chelala L 

PROVIDER: S-EPMC7596344 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature