Neurotrophic effects of dental pulp stem cells in repair of peripheral nerve after crush injury.

ABSTRACT:

Background

Nerve diseases and injuries, which are usually accompanied by motor or sensory dysfunction and disorder, impose a heavy burden upon patients and greatly reduce their quality of life. Dental pulp stem cells (DPSCs), derived from the neural crest, have many characteristics that are similar to those of neural cells, indicating that they can be an ideal source for neural repair.

Aim

To explore the potential roles and molecular mechanisms of DPSCs in crushed nerve recovery.

Methods

DPSCs were isolated, cultured, and identified by multilineage differentiation and flow cytometry. Western blot and immunofluorescent staining were applied to analyze the expression levels of neurotrophic proteins in DPSCs after neural induction. Then, we collected the secretions of DP

SUBMITTER: Wang DR 

PROVIDER: S-EPMC7596440 | biostudies-literature | 2020 Oct

REPOSITORIES: biostudies-literature