Capabilities of multi-pinhole SPECT with two stationary detectors for in vivo rat imaging.

ABSTRACT: We aimed to investigate the image quality of the U-SPECT5/CT E-Class a micro single-photon emission computed tomography (SPECT) system with two large stationary detectors for visualization of rat hearts and bones using clinically available ^99mTc-labelled tracers. Sensitivity, spatial resolution, uniformity and contrast-to-noise ratio (CNR) of the small-animal SPECT scanner were investigated in phantom studies using an ultra-high-resolution rat and mouse multi-pinhole collimator (UHR-RM). Point source, hot-rod, and uniform phantoms with ^99mTc-solution were scanned for high-count performance assessment and count levels equal to animal scans, respectively. Reconstruction was performed using the similarity-regulated ordered-subsets expectation maximization (SROSEM) algori

SUBMITTER: Janssen JP 

PROVIDER: S-EPMC7596477 | biostudies-literature | 2020 Oct

REPOSITORIES: biostudies-literature