Immune checkpoint molecules in natural killer cells as potential targets for cancer immunotherapy.

ABSTRACT: Recent studies have demonstrated the potential of natural killer (NK) cells in immunotherapy to treat multiple types of cancer. NK cells are innate lymphoid cells that play essential roles in tumor surveillance and control that efficiently kill the tumor and do not require the major histocompatibility complex. The discovery of the NK's potential as a promising therapeutic target for cancer is a relief to oncologists as they face the challenge of increased chemo-resistant cancers. NK cells show great potential against solid and hematologic tumors and have progressively shown promise as a therapeutic target for cancer immunotherapy. The effector role of these cells is reliant on the balance of inhibitory and activating signals. Understanding the role of various immune checkpoint molecules in

SUBMITTER: Cao Y 

PROVIDER: S-EPMC7596531 | biostudies-literature | 2020 Oct

REPOSITORIES: biostudies-literature