Prevalence of Hypothyroidism in Patients With Erdheim-Chester Disease.

ABSTRACT:

Importance

Erdheim-Chester disease (ECD) is a rare non-Langerhans cell histiocytosis affecting multiple organs and commonly caused by somatic pathogenic variants in BRAF V600E and mitogen-activated protein kinase genes. Clinical features of ECD result from histiocytic involvement of various tissues; while endocrine involvement in ECD occurs frequently, the prevalence of central or primary hypothyroidism has not been thoroughly investigated.

Objective

To assess hypothalamus-pituitary-thyroid (HPT) dysfunction in patients with ECD.

Design, setting, and participants

This cross-sectional study included 61 patients with ECD who were enrolled in a natural history study at a tertiary care center between January 2011 and December 2018. ECD was diagnosed on the basis of clinic

SUBMITTER: Shekhar S 

PROVIDER: S-EPMC7596581 | biostudies-literature | 2020 Oct

REPOSITORIES: biostudies-literature