Association of Viral Persistence and Atherosclerosis in Adults With Treated HIV Infection.

ABSTRACT:

Importance

Persons living with HIV (PLWH) have increased risk for cardiovascular disease, and inflammation is thought to contribute to this excess risk. Production of HIV during otherwise effective antiretroviral therapy (ART) has been associated with inflammation.

Objective

To determine whether higher levels of viral persistence are associated with atherosclerosis as assessed by changes in carotid artery intima-media thickness (IMT) over time.

Design, setting, and participants

In this cohort study, intima-media thickness, a validated marker of atherosclerosis, was assessed over time in a cohort of treated PLWH with viral suppression. Cell-associated HIV DNA and RNA and change in IMT, adjusted for demographics, cardiovascular risk factors, and HIV-related factors, wer

SUBMITTER: McLaughlin MM 

PROVIDER: S-EPMC7596582 | biostudies-literature | 2020 Oct

REPOSITORIES: biostudies-literature