Fine Mapping of the Major Histocompatibility Complex Region and Association of the HLA-B*52:01 Allele With Cervical Cancer in Japanese Women.

ABSTRACT:

Importance

Understanding the genetic contribution of the major histocompatibility complex (MHC) region to the risk of cervical cancer (CC) will help understand how immune responses to infection with human papillomaviruses are associated with CC.

Objective

To determine whether the HLA-B*52:01 allele is associated with CC in Japanese women.

Design, setting, and participants

This was a multicenter genetic association study. Genotype and phenotype data were obtained from BioBank Japan Project. Additional patients with CC were enrolled from the Aichi Cancer Center Research Institute. An MHC fine-mapping study was conducted on CC risk in the Japanese population by applying a human leukocyte antigen (HLA) imputation method to the large-scale CC genome-wide association study

SUBMITTER: Masuda T 

PROVIDER: S-EPMC7596586 | biostudies-literature | 2020 Oct

REPOSITORIES: biostudies-literature