New strain of Pediococcus pentosaceus alleviates ethanol-induced liver injury by modulating the gut microbiota and short-chain fatty acid metabolism.

ABSTRACT:

Background

Intestinal dysbiosis has been shown to be associated with the pathogenesis of alcoholic liver disease (ALD), which includes changes in the microbiota composition and bacterial overgrowth, but an effective microbe-based therapy is lacking. Pediococcus pentosaceus (P. pentosaceus) CGMCC 7049 is a newly isolated strain of probiotic that has been shown to be resistant to ethanol and bile salts. However, further studies are needed to determine whether P. pentosaceus exerts a protective effect on ALD and to elucidate the potential mechanism.

Aim

To evaluate the protective effect of the probiotic P. pentosaceus on ethanol-induced liver injury in mice.

Methods

A new ethanol-resistant strain of P. pentosaceus CGMCC 7049 was isolate

SUBMITTER: Jiang XW 

PROVIDER: S-EPMC7596634 | biostudies-literature | 2020 Oct

REPOSITORIES: biostudies-literature