Instrumental activities of daily living, amyloid, and cognition in cognitively normal older adults screening for the A4 Study.

ABSTRACT:

Introduction

We examined the associations among instrumental activities of daily living (IADL), cortical amyloid, and cognition in cognitively normal (CN) older adults.

Methods

CN participants screening for the A4 Study (n = 4486) underwent florbetapir (amyloid) positron emission tomography. IADL were assessed using the Alzheimer's Disease Cooperative Study Activities of Daily Living Prevention Instrument. Separate logistic regression models were run with cortical amyloid or cognition as independent variable and IADL as dependent variable, adjusting for age and sex.

Results

IADL difficulties were endorsed infrequently (≤16%). Overall IADL and four select IADL item difficulties ("remembering appointments," "finding belongings," "following TV programs," and "remembering

SUBMITTER: Marshall GA 

PROVIDER: S-EPMC7596668 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature