Adaptive platform trials using multi-arm, multi-stage protocols: getting fast answers in pandemic settings.

ABSTRACT: Global health pandemics, such as coronavirus disease 2019 (COVID-19), require efficient and well-conducted trials to determine effective interventions, such as treatments and vaccinations. Early work focused on rapid sequencing of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), subsequent in-vitro and in-silico work, along with greater understanding of the different clinical phases of the infection, have helped identify a catalogue of potential therapeutic agents requiring assessment. In a pandemic, there is a need to quickly identify efficacious treatments, and reject those that are non-beneficial or even harmful, using randomised clinical trials. Whilst each potential treatment could be investigated across multiple, separate, competing two-arm trials, this is

SUBMITTER: Noor NM 

PROVIDER: S-EPMC7596806 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature