Injectable Hydrogels for Sustained Codelivery of Subunit Vaccines Enhance Humoral Immunity.

ABSTRACT: Vaccines aim to elicit a robust, yet targeted, immune response. Failure of a vaccine to elicit such a response arises in part from inappropriate temporal control over antigen and adjuvant presentation to the immune system. In this work, we sought to exploit the immune system's natural response to extended pathogen exposure during infection by designing an easily administered slow-delivery vaccine platform. We utilized an injectable and self-healing polymer-nanoparticle (PNP) hydrogel platform to prolong the codelivery of vaccine components to the immune system. We demonstrated that these hydrogels exhibit unique delivery characteristics, whereby physicochemically distinct compounds (such as antigen and adjuvant) could be codelivered over the course of weeks. When administered in mice, hydr

SUBMITTER: Roth GA 

PROVIDER: S-EPMC7596866 | biostudies-literature | 2020 Oct

REPOSITORIES: biostudies-literature