Multireceptor targeting of glioblastoma.

ABSTRACT:

Background

Treatment for glioblastoma (GBM) remains an unmet need in medicine. Novel therapies that address GBM complexity and heterogeneity in particular are warranted. To this end, we target 4 tumor-associated receptors at a time that span virtually all of the GBM microenvironment including bulk tumor cells, infiltrating tumor cells, neovasculature, and tumor-infiltrating cells with one pharmaceutical agent delivering a cytotoxic load.

Methods

We engineered multivalent ligand-based vector proteins termed QUAD with an ability to bind to 4 of the following GBM-associated receptors: IL-13RA2, EphA2, EphA3, and EphB2. We conjugated QUAD with a modified bacterial toxin PE38QQR and tested it in vitro and in vivo.

Results

The QUAD variants preserved functional characterist

SUBMITTER: Sharma P 

PROVIDER: S-EPMC7596893 | biostudies-literature | 2020 Jan-Dec

REPOSITORIES: biostudies-literature