Elucidation of molecular links between obesity and cancer through microRNA regulation.

ABSTRACT:

Background

Obesity contributes to high cancer risk in humans and the mechanistic links between these two pathologies are not yet understood. Recent emerging evidence has associated obesity and cancer with metabolic abnormalities and inflammation where microRNA regulation has a strong implication.

Methods

In this study, we have developed an integrated framework to unravel obesity-cancer linkage from a microRNA regulation perspective. Different from traditional means of identifying static microRNA targets based on sequence and structure properties, our approach focused on the discovery of context-dependent microRNA-mRNA interactions that are potentially associated with disease progression via large-scale genomic analysis. Specifically, a meta-regression analysis and the integr

SUBMITTER: Dogan H 

PROVIDER: S-EPMC7596939 | biostudies-literature | 2020 Oct

REPOSITORIES: biostudies-literature