The selectivity filter of the mitochondrial protein import machinery.

ABSTRACT:

Background

The uptake of newly synthesized nuclear-encoded mitochondrial proteins from the cytosol is mediated by a complex of mitochondrial outer membrane proteins comprising a central pore-forming component and associated receptor proteins. Distinct fractions of proteins initially bind to the receptor proteins and are subsequently transferred to the pore-forming component for import. The aim of this study was the identification of the decisive elements of this machinery that determine the specific selection of the proteins that should be imported.

Results

We identified the essential internal targeting signal of the members of the mitochondrial metabolite carrier proteins, the largest protein family of the mitochondria, and we investigated the specific recognition of this s

SUBMITTER: Kreimendahl S 

PROVIDER: S-EPMC7596997 | biostudies-literature | 2020 Oct

REPOSITORIES: biostudies-literature