The CBP KIX domain regulates long-term memory and circadian activity.

ABSTRACT:

Background

CREB-dependent transcription necessary for long-term memory is driven by interactions with CREB-binding protein (CBP), a multi-domain protein that binds numerous transcription factors potentially affecting expression of thousands of genes. Identifying specific domain functions for multi-domain proteins is essential to understand processes such as cognitive function and circadian clocks. We investigated the function of the CBP KIX domain in hippocampal memory and gene expression using CBP^KIX/KIX mice with mutations that prevent phospho-CREB (Ser133) binding.

Results

We found that CBP^KIX/KIX mice were impaired in long-term memory, but not learning acquisition or short-term memory for the Morris water maze. Using an unbiased analysis of gene exp

SUBMITTER: Chatterjee S 

PROVIDER: S-EPMC7597000 | biostudies-literature | 2020 Oct

REPOSITORIES: biostudies-literature