Fitness effects for Ace insecticide resistance mutations are determined by ambient temperature.

ABSTRACT:

Background

Insect pest control programs often use periods of insecticide treatment with intermittent breaks, to prevent fixing of mutations conferring insecticide resistance. Such mutations are typically costly in an insecticide-free environment, and their frequency is determined by the balance between insecticide treatment and cost of resistance. Ace, a key gene in neuronal signaling, is a prominent target of many insecticides and across several species, three amino acid replacements (I161V, G265A, and F330Y) provide resistance against several insecticides. Because temperature disturbs neuronal signaling homeostasis, we reasoned that the cost of insecticide resistance could be modulated by ambient temperature.

Results

Experimental evolution of a natural Drosophila simulans

SUBMITTER: Langmuller AM 

PROVIDER: S-EPMC7597021 | biostudies-literature | 2020 Oct

REPOSITORIES: biostudies-literature