Decline in cognitively complex everyday activities accelerates along the Alzheimer's disease continuum.

ABSTRACT:

Background

Impairment in daily functioning is a clinical hallmark of dementia. Difficulties with "instrumental activities of daily living" (IADL) seem to increase gradually over the course of Alzheimer's disease (AD), before dementia onset. However, it is currently not well established how difficulties develop along the preclinical and prodromal stages of AD. We aimed to investigate the trajectories of decline in IADL performance, as reported by a study partner, along the early stages of AD.

Methods

In a longitudinal multicenter study, combining data from community-based and memory clinic cohorts, we included 1555 individuals (mean age 72.5 ± 7.8 years; 50% female) based on availability of amyloid biomarkers, longitudinal IADL data, and clinical information at baseline. Medi

SUBMITTER: Dubbelman MA 

PROVIDER: S-EPMC7597034 | biostudies-literature | 2020 Oct

REPOSITORIES: biostudies-literature