Treatment of Inflammatory Diseases with IL-1 Blockade.

ABSTRACT:

Background

Autoinflammatory diseases are distinct from autoimmune diseases. Whereas autoinflammatory diseases are due to dysfunctional T-cells and B-cells, autoinflammatory diseases are due to overproduction of macrophage cytokines particularly interleukin-1 beta (IL-1β). A causative role for IL-1 in autoinflammatory diseases is derived from clinical studies blocking the IL-1 receptor or neutralizing monoclonal antibodies or soluble receptors.

Methods

A review was performed of clinical trials in autoinflammatory diseases using the IL-1 receptor antagonist (anakinra), the soluble IL-1 receptor (rilonacept), antibodies to IL-1β (canakinumab, gevokizumab) and anti-IL-1α (xilonix).

Findings

Anakinra blocks the IL-1 Receptor type 1 (IL-1R1) and therefore blocks the activit

SUBMITTER: Dinarello CA 

PROVIDER: S-EPMC7597638 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature