Endogenous avian leukosis virus subgroup E elements of the chicken reference genome.

ABSTRACT: The chicken reference genome contains 2 endogenous avian leukosis virus subgroup E (ALVE) insertions, but gaps and unresolved repetitive sequences in previous assemblies have hindered their precise characterization. Detailed analysis of the most recent reference genome (GRCg6a) now shows both ALVEs within contiguous chromosome assemblies for the first time. ALVE6 (ALVE-JFevA) and ALVE-JFevB are both located on chromosome 1, with ALVE6 close to the p-arm telomere. ALVE-JFevB is a structurally intact element containing the ALVE gag, pol, and env genes and is capable of forming replication competent viruses. In contrast, ALVE6 contains a 3,352 bp 5' truncation and lacks the entire 5' long terminal repeat and gag gene. Despite this, ALVE6 remains able to produce intact envelope protein, likely

SUBMITTER: Mason AS 

PROVIDER: S-EPMC7597685 | biostudies-literature | 2020 Jun

REPOSITORIES: biostudies-literature