Collagen scaffolds functionalized with triple-helical peptides support 3D HUVEC culture.

ABSTRACT: Porous biomaterials which provide a structural and biological support for cells have immense potential in tissue engineering and cell-based therapies for tissue repair. Collagen biomaterials that can host endothelial cells represent promising tools for the vascularization of engineered tissues. Three-dimensional collagen scaffolds possessing controlled architecture and mechanical stiffness are obtained through freeze-drying of collagen suspensions, followed by chemical cross-linking which maintains their stability. However, cross-linking scaffolds renders their biological activity suboptimal for many cell types, including human umbilical vein endothelial cells (HUVECs), by inhibiting cell-collagen interactions. Here, we have improved crucial HUVEC interactions with such cross-linked collag

SUBMITTER: Malcor JD 

PROVIDER: S-EPMC7597804 | biostudies-literature | 2020 Oct

REPOSITORIES: biostudies-literature