Preparation of phospholipid-based polycarbonate urethanes for potential applications of blood-contacting implants.

ABSTRACT: Polyurethanes are widely used in interventional devices due to the excellent physicochemical property. However, non-specific adhesion and severe inflammatory response of ordinary polyurethanes may lead to severe complications of intravenous devices. Herein, a novel phospholipid-based polycarbonate urethanes (PCUs) were developed via two-step solution polymerization by direct synthesis based on functional raw materials. Furthermore, PCUs were coated on biomedical metal sheets to construct biomimetic anti-fouling surface. The results of stress-strain curves exhibited excellent tensile properties of PCUs films. Differential scanning calorimetry results indicated that the microphase separation of such PCUs polymers could be well regulated by adjusting the formulation of chain extender,

SUBMITTER: Li P 

PROVIDER: S-EPMC7597807 | biostudies-literature | 2020 Oct

REPOSITORIES: biostudies-literature