Ontology highlight
ABSTRACT:
SUBMITTER: Wiles TA
PROVIDER: S-EPMC7597855 | biostudies-literature | 2019 Mar
REPOSITORIES: biostudies-literature
Journal of proteome research 20190103 3
We recently discovered hybrid insulin peptides (HIPs) as a novel class of post-translationally modified peptides in murine-derived beta cell tumors, and we demonstrated that these molecules are autoantigens in type 1 diabetes (T1D). A HIP consists of an insulin fragment linked to another secretory granule peptide via a peptide bond. We verified that autoreactive CD4 T cells in both mouse and human autoimmune diabetes recognize these modified peptides. Here, we use mass spectrometric analyses to ...[more]