Genomic Profiling of Prostate Cancers from Men with African and European Ancestry.

ABSTRACT:

Purpose

African American (AFR) men have the highest mortality rate from prostate cancer (PCa) compared with men of other racial/ancestral groups. Differences in the spectrum of somatic genome alterations in tumors between AFR men and other populations have not been well-characterized due to a lack of inclusion of significant numbers in genomic studies.

Experimental design

To identify genomic alterations associated with race, we compared the frequencies of somatic alterations in PCa obtained from four publicly available datasets comprising 250 AFR and 611 European American (EUR) men and a targeted sequencing dataset from a commercial platform of 436 AFR and 3018 EUR men.

Results

Mutations in ZFHX3 as well as focal deletions in ETV3 were more frequent in t

SUBMITTER: Koga Y 

PROVIDER: S-EPMC7597977 | biostudies-literature | 2020 Sep

REPOSITORIES: biostudies-literature