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Comment: Mis-Genotyping of Some Hepatitis D Virus Genotype 2 and 5 Sequences Using HDVdb.

ABSTRACT: Evidence that Hepatitis D virus (HDV) genotype is involved in HDV infection pathogenesis is increasing. Indeed, HDV genotypes have been shown to be linked to different outcomes in terms of liver fibrosis and treatment response. Herein, we show that the promising HDVdb genotyping tool available online can lead to wrong genotyping results. The current HDVdb algorithm should be carefully considered as a "beta-version" and warrants algorithm core corrections, as soon as possible, for an optimal and beneficial use.

SUBMITTER: Charre C

PROVIDER: S-EPMC7598266 | biostudies-literature | 2020 Sep

REPOSITORIES: biostudies-literature

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Comment: Mis-Genotyping of Some Hepatitis D Virus Genotype 2 and 5 Sequences Using HDVdb.

Charre Caroline C le Gal Frédéric F Dény Paul P Scholtès Caroline C

Viruses 20200923 10

Evidence that Hepatitis D virus (HDV) genotype is involved in HDV infection pathogenesis is increasing. Indeed, HDV genotypes have been shown to be linked to different outcomes in terms of liver fibrosis and treatment response. Herein, we show that the promising HDVdb genotyping tool available online can lead to wrong genotyping results. The current HDVdb algorithm should be carefully considered as a "beta-version" and warrants algorithm core corrections, as soon as possible, for an optimal and ...[more]

PMID: 32977660

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