Progress Overview of Bacterial Two-Component Regulatory Systems as Potential Targets for Antimicrobial Chemotherapy.

ABSTRACT: Bacteria adapt to changes in their environment using a mechanism known as the two-component regulatory system (TCS) (also called "two-component signal transduction system" or "two-component system"). It comprises a pair of at least two proteins, namely the sensor kinase and the response regulator. The former senses external stimuli while the latter alters the expression profile of bacterial genes for survival and adaptation. Although the first TCS was discovered and characterized in a non-pathogenic laboratory strain of Escherichia coli, it has been recognized that all bacteria, including pathogens, use this mechanism. Some TCSs are essential for cell growth and fitness, while others are associated with the induction of virulence and drug resistance/tolerance. Therefore, the TCS is propose

SUBMITTER: Hirakawa H 

PROVIDER: S-EPMC7598275 | biostudies-literature | 2020 Sep

REPOSITORIES: biostudies-literature