Intrahepatic interleukin 10 expression modulates fibrinogenesis during chronic HCV infection.

ABSTRACT:

Introduction

Liver fibrosis is a result of continuous damage to the liver combined with accumulation of the extracellular matrix and is characteristic of most chronic liver diseases such as hepatitis C virus (HCV) infection.

Methods

This study evaluated interleukin 10 (IL10) expression in the liver and plasma of 45 HCV patients and its association with the pathogenesis and progression of liver fibrosis. The expression of transforming growth factor beta (TGFB1) was also assessed. Patients were divided into three groups according to the METAVIR classification (F0-F1, F2 and F3-F4); there was also a control group (n = 8).

Results

In the control group, high intrahepatic IL10 mRNA expression showed a positive association with F0-F1 fibrosis, no inflammation, low concentrat

SUBMITTER: Amoras EDSG 

PROVIDER: S-EPMC7598451 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature