Succinivibrionaceae is dominant family in fecal microbiota of Behcet's Syndrome patients with uveitis.

ABSTRACT: Behçet's Syndrome (BS) is a multisystem vasculitis with various clinical manifestations. Pathogenesis is unclear, but studies have shown genetic factors, innate immunity and autoinflammation to have an important role in the disease course. Diversity in the microbial community of gut microbiota may significantly contribute to the activation of the innate immune system. The clinical features of BS present themselves in clusters and each cluster may be a consequence of different disease mechanisms. For this reason we aimed to investigate the gut microbiota of BS patients with uveitis. In addition to healthy controls, we have aimed to compare the gut microbiota of BS with that of Familial Mediterranean Fever (FMF) and Crohn's Disease (CD) as both diseases have innate and autoinflammatory featu

SUBMITTER: Tecer D 

PROVIDER: S-EPMC7598488 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature