Genetics of Arthrogryposis and Macroglossia in Piemontese Cattle Breed.

ABSTRACT: Arthrogryposis and macroglossia are congenital pathologies known in several cattle breeds, including Piemontese. As variations in single genes were identified as responsible for arthrogryposis in some breeds, we decided: (i) to test the hypothesis of a similar genetic determinism for arthrogryposis in the Piemontese breed by genotyping affected and healthy animals with a high-density chip and applying genome-wide association study (GWAS), F_ST and canonical discriminant analysis (CDA) procedures, and (ii) to investigate with the same approach the genetic background of macroglossia, for which no genetic studies exist so far. The study included 125 animals (63 healthy, 30 with arthrogryposis, and 32 with macroglossia). Differently from what reported for other breeds, the ana

SUBMITTER: Di Stasio L 

PROVIDER: S-EPMC7598642 | biostudies-literature | 2020 Sep

REPOSITORIES: biostudies-literature