Increased Lamin B1 Levels Promote Cell Migration by Altering Perinuclear Actin Organization.

ABSTRACT: Cell migration requires reposition and reshaping of the cell nucleus. The nuclear lamina is highly important for migration of both primary and cancer cells. B-type lamins are important for proper migration of epicardial cells and neurons and increased lamin B to lamin A ratio accelerates cancer cell migration through confined spaces. Moreover, a positive association between lamin B1 levels and tumor formation and progression is found in various cancer types. Still, the molecular mechanism by which B-type lamins promote cell migration is not fully understood. To better understand this mechanism, we tested the effects of lamin B1 on perinuclear actin organization. Here we show that induction of melanoma cell migration leads to the formation of a cytosolic Linker of Nucleoskeleton and Cytoske

SUBMITTER: Fracchia A 

PROVIDER: S-EPMC7598699 | biostudies-literature | 2020 Sep

REPOSITORIES: biostudies-literature