Grafting with RAFT-gRAFT Strategies to Prepare Hybrid Nanocarriers with Core-shell Architecture.

ABSTRACT: Stimuli-responsive polymer materials are used in smart nanocarriers to provide the stimuli-actuated mechanical and chemical changes that modulate cargo delivery. To take full advantage of the potential of stimuli-responsive polymers for controlled delivery applications, these have been grafted to the surface of mesoporous silica particles (MSNs), which are mechanically robust, have very large surface areas and available pore volumes, uniform and tunable pore sizes and a large diversity of surface functionalization options. Here, we explore the impact of different RAFT-based grafting strategies on the amount of a pH-responsive polymer incorporated in the shell of MSNs. Using a "grafting to" (gRAFT-to) approach we studied the effect of polymer chain size on the amount of polymer in th

SUBMITTER: L M Goncalves J 

PROVIDER: S-EPMC7598713 | biostudies-literature | 2020 Sep

REPOSITORIES: biostudies-literature