SeekCRIT: Detecting and characterizing differentially expressed circular RNAs using high-throughput sequencing data.

ABSTRACT: Over the past two decades, researchers have discovered a special form of alternative splicing that produces a circular form of RNA. Although these circular RNAs (circRNAs) have garnered considerable attention in the scientific community for their biogenesis and functions, the focus of current studies has been on the tissue-specific circRNAs that exist only in one tissue but not in other tissues or on the disease-specific circRNAs that exist in certain disease conditions, such as cancer, but not under normal conditions. This approach was conducted in the relative absence of methods that analyze a group of common circRNAs that exist in both conditions, but are more abundant in one condition relative to another (differentially expressed). Studies of differentially expressed circRNAs (DECs) be

SUBMITTER: Chaabane M 

PROVIDER: S-EPMC7598922 | biostudies-literature | 2020 Oct

REPOSITORIES: biostudies-literature