The gut microbiome in differential diagnosis of diabetic kidney disease and membranous nephropathy.

ABSTRACT:

Background

Diabetic kidney disease (DKD) and membranous nephropathy (MN) are the two major causes of end-stage renal disease (ESRD). Increasing evidence has shown that intestinal dysbiosis is associated with many diseases. The aim of this study was to explore the composition of the gut microbiome in DKD and MN patients.

Methods

16S rRNA gene sequencing was performed on 271 fecal samples (DKD = 129 and MN = 142), and taxonomic annotation of microbial composition and function was completed.

Results

We observed distinct microbial communities between the two groups, with MN samples exhibiting more severe dysbiosis than DKD samples. Relative increases in genera producing short-chain fatty acids (SCFAs) in DKD and a higher proportion of potential pathogens in MN were the ma

SUBMITTER: Yu W 

PROVIDER: S-EPMC7599019 | biostudies-literature | 2020 Nov

REPOSITORIES: biostudies-literature