Imaging cardiac innervation in hereditary transthyretin (ATTRm) amyloidosis: A marker for neuropathy or cardiomyopathy in case of heart failure?

ABSTRACT:

Background

Nuclear imaging modalities using ¹²³Iodine-metaiodobenzylguanidine (¹²³I-MIBG) and bone seeking tracers identify early cardiac involvement in ATTRm amyloidosis patients. However, little is known whether results from ¹²³I-MIBG scintigraphy actually correlate to markers for either cardiac autonomic neuropathy or cardiomyopathy.

Methods

All TTR mutation carriers and ATTRm patients who underwent both ¹²³I-MIBG and ^99mTechnetium-hydroxymethylene diphosphonate (^99mTc-HDP) scintigraphy were included. Cardiomyopathy was defined as NT-proBNP > 365 ng/L, and cardiac autonomic neuropathy as abnormal cardiovascular reflexes at autonomic function tests. Late ¹²³I-MIBG heart-to-mediastinum ratio (HMR) 

SUBMITTER: Jonker DL 

PROVIDER: S-EPMC7599160 | biostudies-literature | 2020 Oct

REPOSITORIES: biostudies-literature