Sclerostin is an independent risk factor for all-cause mortality in kidney transplant recipients.

ABSTRACT:

Background

Sclerostin is a hormone contributing to the bone-vascular wall cross talk and has been implicated in cardiovascular events and mortality in patients with chronic kidney disease (CKD). We analyzed the relationship between sclerostin and mortality in renal transplant recipients.

Methods

600 stable renal transplant recipients (367men, 233 women) were followed for all-cause mortality for 3 years. Blood and urine samples for analysis and clinical data were collected at study entry. We performed Kaplan-Meier survival analysis and Cox regression models considering confounding factors such as age, eGFR, cold ischemia time, HbA1c, phosphate, calcium, and albumin. Optimal cut-off values for the Cox regression model were calculated based on ROC analysis.

Results

Sixty

SUBMITTER: Zeng S 

PROVIDER: S-EPMC7599189 | biostudies-literature | 2020 Dec

REPOSITORIES: biostudies-literature