Association of a dysbiotic oral microbiota with the development of focal lymphocytic sialadenitis in IκB-ζ-deficient mice.

ABSTRACT: Mice lacking IκB-ζ, a protein encoded by the Nfkbiz gene, spontaneously develop a Sjögren's syndrome-like disease involving the lachrymal glands, but no salivary gland symptoms have been reported. We found that Nfkbiz^-/- female mice presented a significantly reduced salivary flow rate, focal lymphocytic sialadenitis (FLS), and a dysbiotic oral microbiota at week 24. To dissect the contributions of genetic and environmental factors to the salivary gland phenotype, Nfkbiz^+/+ and Nfkbiz^-/- mice were cohoused after weaning and evaluated at week 20. Cohousing alleviated the salivary gland phenotype of Nfkbiz^-/- mice but did not induce any disease phenotype in Nfkbiz^+/+ mice. Additionally, the oral microbiota in the cohoused mice was synchro

SUBMITTER: Lee J 

PROVIDER: S-EPMC7599236 | biostudies-literature | 2020 Oct

REPOSITORIES: biostudies-literature