Gastrointestinal predictors of severe COVID-19: systematic review and meta-analysis.

ABSTRACT:

Background

COVID-19 pandemic has created a need to identify potential predictors of severe disease. We performed a systematic review and meta-analysis of gastrointestinal predictors of severe COVID-19.

Methods

An extensive literature search was performed using PubMed, Embase, Web of Science and Cochrane. Odds ratio (OR) and mean difference (MD) were calculated for proportional and continuous outcomes using a random-effect model. For each outcome, a 95% confidence interval (CI) and P-value were generated.

Results

A total of 83 studies (26912 patients, mean age 43.5±16.4 years, 48.2% female) were included. Gastrointestinal predictors of severe COVID-19 included the presence of diarrhea (OR 1.50, 95%CI 1.10-2.03; P=0.01), elevated serum aspartate aminotransferase (AST) (

SUBMITTER: Aziz M 

PROVIDER: S-EPMC7599357 | biostudies-literature | 2020 Nov-Dec

REPOSITORIES: biostudies-literature