Ontology highlight
ABSTRACT:
SUBMITTER: Pardella E
PROVIDER: S-EPMC7599540 | biostudies-literature | 2020 Sep
REPOSITORIES: biostudies-literature
Pardella Elisa E Pranzini Erica E Leo Angela A Taddei Maria Letizia ML Paoli Paolo P Raugei Giovanni G
Cancers 20200929 10
Despite a large number of therapeutic options available, malignant melanoma remains a highly fatal disease, especially in its metastatic forms. The oncogenic role of protein tyrosine phosphatases (PTPs) is becoming increasingly clear, paving the way for novel antitumor treatments based on their inhibition. In this review, we present the oncogenic PTPs contributing to melanoma progression and we provide, where available, a description of new inhibitory strategies designed against these enzymes an ...[more]