Glycosylation Alterations in Multiple Sclerosis Show Increased Proinflammatory Potential.

ABSTRACT: Multiple sclerosis (MS) is an inflammatory autoimmune disorder affecting the central nervous system (CNS), with unresolved aetiology. Previous studies have implicated N-glycosylation, a highly regulated enzymatic attachment of complex sugars to targeted proteins, in MS pathogenesis. We investigated individual variation in N-glycosylation of the total plasma proteome and of IgG in MS. Both plasma protein and IgG N-glycans were chromatographically profiled and quantified in 83 MS cases and 88 age- and sex-matched controls. Comparing levels of glycosylation features between MS cases and controls revealed that core fucosylation (p = 6.96 × 10^-3) and abundance of high-mannose structures (p = 1.48 × 10^-2) were the most prominently altered IgG glycosylation tra

SUBMITTER: Cvetko A 

PROVIDER: S-EPMC7599553 | biostudies-literature | 2020 Oct

REPOSITORIES: biostudies-literature