The Association of Residential Altitude on the Molecular Profile and Survival of Melanoma: Results of an Interreg Study.

ABSTRACT: Cutaneous melanoma (CM) incidence is rising worldwide and is the primary cause of death from skin disease in the Western world. Personal risk factors linked to environmental ultraviolet radiation (UVR) are well-known etiological factors contributing to its development. Nevertheless, UVR can contribute to the development of CM in different patterns and to varying degrees. The present study aimed at investigating whether altitude of residence can contribute to the development of specific types of CM and/or influence its progression. To this aim, 306 formalin-fixed and paraffin-embedded (FFPE) tissues from primary CM diagnosed in different geographical areas were submitted to B-RAF proto-oncogene serine/threonine kinase (BRAF) and N-RAS proto-oncogene GTPase (NRAS) mutational status detection

SUBMITTER: De Martino E 

PROVIDER: S-EPMC7599639 | biostudies-literature | 2020 Sep

REPOSITORIES: biostudies-literature