Isoeugenol and Hybrid Acetamides against Candida albicans Isolated from the Oral Cavity.

ABSTRACT: Isougenol is a phytoconstituent found in several essential oils. Since many natural products are potent antimicrobials, the synthesis of hybrid molecules-combining the chemical skeleton of the phytochemical with synthetic groups-can generate substances with enhanced biological activity. Based on this, the objective of this study was to evaluate the antifungal activity of isoeugenol and hybrid acetamides against Candida albicans isolated from the oral cavity. The methodologies used were the determination of minimum inhibitory concentration (MIC), minimum fungicidal concentration (MFC), action on fungal micromorphology, interaction test with nystatin by the checkerboard method and molecular docking study with important enzymes in the maintenance of fungal viability. The synthetic mole

SUBMITTER: Medeiros D 

PROVIDER: S-EPMC7599878 | biostudies-literature | 2020 Oct

REPOSITORIES: biostudies-literature