Gellan Gum Promotes the Differentiation of Enterocytes from Human Induced Pluripotent Stem Cells.

ABSTRACT: The evaluation of drug pharmacokinetics in the small intestine is critical for developing orally administered drugs. Caucasian colon adenocarcinoma (Caco-2) cells are employed to evaluate drug absorption in preclinical trials of drug development. However, the pharmacokinetic characteristics of Caco-2 cells are different from those of the normal human small intestine. Besides this, it is almost impossible to obtain primary human intestinal epithelial cells of the same batch. Therefore, human iPS cell-derived enterocytes (hiPSEs) with pharmacokinetic functions similar to human intestinal epithelial cells are expected to be useful for the evaluation of drug absorption. Previous studies have been limited to the use of cytokines and small molecules to generate hiPSEs. Dietary fibers play a crit

SUBMITTER: Qiu S 

PROVIDER: S-EPMC7599917 | biostudies-literature | 2020 Oct

REPOSITORIES: biostudies-literature