Impact of Electronic Health Record Interface Design on Unsafe Prescribing of Ciclosporin, Tacrolimus, and Diltiazem: Cohort Study in English National Health Service Primary Care.

ABSTRACT:

Background

In England, national safety guidance recommends that ciclosporin, tacrolimus, and diltiazem are prescribed by brand name due to their narrow therapeutic windows and, in the case of tacrolimus, to reduce the chance of organ transplantation rejection. Various small studies have shown that changes to electronic health record (EHR) system interfaces can affect prescribing choices.

Objective

Our objectives were to assess variation by EHR systems in breach of safety guidance around prescribing of ciclosporin, tacrolimus, and diltiazem, and to conduct user-interface research into the causes of such breaches.

Methods

We carried out a retrospective cohort study using prescribing data in English primary care. Participants were English general practices and their resp

SUBMITTER: MacKenna B 

PROVIDER: S-EPMC7600019 | biostudies-literature | 2020 Oct

REPOSITORIES: biostudies-literature