Impacts of platinum-based chemotherapy on subsequent testicular function and fertility in boys with cancer.

ABSTRACT:

Background

Children with cancer often face infertility as a long-term complication of their treatment. For boys, compromised testicular function is common after chemotherapy and currently there are no well-established options to prevent this damage. Platinum-based agents are used to treat a wide variety of childhood cancers. However, platinum agents are not currently included in the cyclophosphamide equivalent dose (CED), which is used clinically to assess the risks to fertility posed by combination chemotherapy in children with cancer.

Objective and rationale

This was a systematic search of the literature designed to determine the evidence for effects of platinum-based cancer treatment on the prepubertal human testis in relation to subsequent testicular function and fertili

SUBMITTER: Tian En L 

PROVIDER: S-EPMC7600277 | biostudies-literature | 2020 Nov

REPOSITORIES: biostudies-literature