Moderate SIRT1 overexpression protects against brown adipose tissue inflammation.

ABSTRACT:

Objective

Metainflammation is a chronic low-grade inflammatory state induced by obesity and associated comorbidities, including peripheral insulin resistance. Brown adipose tissue (BAT), a therapeutic target against obesity, is an insulin target tissue sensitive to inflammation. Therefore, it is necessary to find strategies to protect BAT against the effects of inflammation in energy balance. In this study, we explored the impact of moderate sirtuin 1 (SIRT1) overexpression on insulin sensitivity and β-adrenergic responses in BAT and brown adipocytes (BA) under pro-inflammatory conditions.

Methods

The effect of inflammation on BAT functionality was studied in obese db/db mice and lean wild-type (WT) mice or mice with moderate overexpression of SIRT1 (SIRT1^Tg+) inj

SUBMITTER: Escalona-Garrido C 

PROVIDER: S-EPMC7600394 | biostudies-literature | 2020 Dec

REPOSITORIES: biostudies-literature