IL-12 and IL-23-Close Relatives with Structural Homologies but Distinct Immunological Functions.

ABSTRACT: Cytokines of the IL-12 family show structural similarities but have distinct functions in the immune system. Prominent members of this cytokine family are the pro-inflammatory cytokines IL-12 and IL-23. These two cytokines share cytokine subunits and receptor chains but have different functions in autoimmune diseases, cancer and infections. Accordingly, structural knowledge about receptor complex formation is essential for the development of new therapeutic strategies preventing and/or inhibiting cytokine:receptor interaction. In addition, intracellular signaling cascades can be targeted to inhibit cytokine-mediated effects. Single nucleotide polymorphisms can lead to alteration in the amino acid sequence and thereby influencing protein functions or protein-protein interactions. To underst

SUBMITTER: Floss DM 

PROVIDER: S-EPMC7600943 | biostudies-literature | 2020 Sep

REPOSITORIES: biostudies-literature